Proteome Exploration Laboratory
Research

"Creativity is Contagious. Pass it on."

- Albert Einstein

Collaborative Work

We are interdisciplinary scientists who like to collaborate. We keep ourselves open to new collaborations and encourage you to contact us to find out more about this possibility. Ideally, we would like to get involved prior to a grant application so that the best strategies can be identified and submitted. At the same time, we are also dedicated to help gathering new results for new grant applications. Depending on your and our staff's commitment we try to accommodate your needs. We also offer training for graduate students and postdocs from other labs who wish to be trained in mass spectrometry and proteomics.

We do research in both, applied and basic sciences. Select examples are given below.

Basic Science: Increasing the Proteomic Depth

For many biological questions ultimate success of an experiment depends heavily on our ability to achieve maximum proteomic depth. Therefore, we devote a substantial amount of our time in optimization studies regarding sample preparation, LC and MS operation and bioinformatics analyses. Our dedication to excellence allows us to achieve some of the highest protein identification rates reported, thus achieving high proteomic depth.

Increase proteomic depth

Applied Science: Posttranslational Modifications

The determination of posttranslational modifications of proteins is another important part of our work. Mass Spectrometry techniques often allow the very specific identification of known and novel posttranslational modifications. The analysis of these modification greatly contributes to the understanding of signaling cascades and protein functions.

PTM analysis

Applied and Basic Science: Histones

Histones regulate gene transcription, DNA damage repair and replication through post-translational modifications (PTMs). We develop and use novel middle-down analyses to analyze histones in unprecedented depth.

Histone analysis

Applied and Basic Science: Neuronal regeneration

We have developed an interest in studying neuronal regeneration in echinoderms. We use a combination of transcriptomics, proteomics and microsopy.

Neuronal regeneration

Basic Science: Development of Electrochemical Electrospray Ionization Techniques

One of our basic study fields is the development of corona discharge electrochemical electrospray ionization techniques, which we plan to apply directly to the study of posttranslational modifications.

Electrochemical Electrospray Ionization